How common is cold autoimmune hemolytic anemia?
Cold AIHA is quite rare. Cold agglutinin disease, one type of cold AIHA, develops in only about 1 in every million cases of autoimmune hemolytic anemia. This makes it an extremely uncommon condition.
Overall, AIHA itself affects about 1 to 3 people per every 100,000 each Show Full Answer
How common is cold autoimmune hemolytic anemia?
Cold AIHA is quite rare. Cold agglutinin disease, one type of cold AIHA, develops in only about 1 in every million cases of autoimmune hemolytic anemia. This makes it an extremely uncommon condition.
Overall, AIHA itself affects about 1 to 3 people per every 100,000 each year. Since cold AIHA makes up a small portion of all AIHA cases (with warm AIHA accounting for 60 to 80 percent of cases), cold AIHA is relatively uncommon compared to the warm type.
November 24, 2025